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Immunization of children with inflammatory bowel disease against SARS-CoV-19 infection: A prospective single centre

Dóra Dohos1,2, Anna Karoliny2, Eszter Gombos2

  • 1Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary.

Vaccine: X
|October 12, 2023
PubMed

Insights

Children with inflammatory bowel disease (IBD) showed effective SARS-CoV-2 antibody responses after COVID-19 vaccination. Antibody levels decreased over six months, underscoring the need for booster immunizations in this population.

Area of Science:

  • Pediatrics
  • Immunology
  • Gastroenterology

Background:

  • Limited real-world data exists on the immune response of children with inflammatory bowel disease (IBD) following SARS-CoV-2 vaccination.
  • Understanding vaccine effectiveness in pediatric IBD patients, particularly those on immunosuppressive therapy, is crucial.

Purpose of the Study:

  • To evaluate the antibody kinetics in children with IBD up to six months after receiving a COVID-19 mRNA vaccine.
  • To assess the duration of seropositivity and antibody titers in this vulnerable pediatric population.

Main Methods:

  • A prospective, observational study was conducted.
  • Antibody levels against the SARS-CoV-2 spike protein were measured in 24 children with IBD at five weeks and six months post-vaccination.
  • The study included 22 children on immunosuppressive treatment.

Main Results:

  • Within five weeks, 95% of participants demonstrated positive spike protein antibody levels.
  • All children with IBD maintained seropositivity at the six-month follow-up.
  • A notable decrease in antibody titers was observed over the six-month period.

Conclusions:

  • SARS-CoV-2 immunization is effective in children with IBD, including those on immunosuppressive therapy.
  • Antibody levels wane over time, indicating a potential decline in protection.
  • These findings emphasize the critical importance of booster vaccinations to maintain immunity in pediatric IBD patients.
Abstract

Keywords:
COVID-19 infectionChildrenIBDImmunizationSARS-CoV2 immunization

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