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Rapid Isolation of BMPR-IB+ Adipose-Derived Stromal Cells for Use in a Calvarial Defect Healing Model
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RANK-L inhibitor as a promising agent for refractory extensive craniofacial fibrous dysplasia: A case report
Moataz D Abouammo1,2, Mohammad Bilal Alsavaf2,3, Daniel M Prevedello2,3
1Department of Otolaryngology - Head and Neck Surgery, Tanta University, Tanta, Egypt.
Background:
McCune-Albright syndrome is a rare disorder characterized by polyostotic fibrous dysplasia (FD), café-au-lait skin pigmentation, and endocrine dysfunction. Extensive FD in the craniofacial region can present significant challenges in terms of disease control and carries a high risk of permanent visual impairment.
Methods:
We present a case of medically and surgically resistant FD that required nine optic nerve decompressions.
Results:
The condition was ultimately controlled with the use of the denosumab agent.
Conclusion:
The case highlights the importance and potential efficacy of denosumab in resistant FD management, particularly in cases involving sensitive organs.
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