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Updated: Jul 13, 2025

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Published on: December 10, 2016
Flagellin is essential for initial attachment to mucosal surfaces by Clostridioides difficile
Ben Sidner1, Armando Lerma1, Baishakhi Biswas1
1Department of Food Science and Technology, University of Nebraska-Lincoln , Lincoln, Nebraska, USA.
Importance:
Clostridioides difficile is one of the leading causes of hospital-acquired infections worldwide and presents challenges in treatment due to recurrent gastrointestinal disease after treatment with antimicrobials. The mechanisms by which C. difficile colonizes the gut represent a key gap in knowledge, including its association with host cells and mucosa. Our results show the importance of flagellin for specific adhesion to mucosal hydrogels and can help to explain prior observations of adhesive defects in flagellin and pilin mutants.
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