Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

12
During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
12
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Longitudinal Research02:20

Longitudinal Research

12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

21
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
21
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

81
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
81

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tau topography subtypes account for clinical heterogeneity and longitudinal trajectories in early-onset Alzheimer's disease.

Brain communications·2026
Same author

Cognitive dispersion profiles and prediction of cognitive change in early-onset dementias: Results from LEADS.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Criterion and convergent validity of plasma biomarkers in early-onset Alzheimer's disease: Initial findings from LEADS.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Network-based cortical atrophy predicts longitudinal clinical decline in sporadic behavioral variant frontotemporal dementia.

Alzheimer's & dementia (Amsterdam, Netherlands)·2026
Same author

Detecting short-interval longitudinal cortical atrophy in neurodegenerative dementias via cluster scanning: A proof of concept.

Imaging neuroscience (Cambridge, Mass.)·2026
Same author

Distinct Tau PET Dynamics in Early vs. Late Age-of-Onset Alzheimer's disease.

medRxiv : the preprint server for health sciences·2026
Same journal

Medicare Advantage Prior-Authorizations Are Linked to Racial Differences in End-of-Life Home Health Use.

Journal of the American Geriatrics Society·2026
Same journal

An Electronic Health Record "Nudge" to Reduce Antipsychotic Medication Prescribing for Primary Care Patients With Dementia: A Pragmatic RCT.

Journal of the American Geriatrics Society·2026
Same journal

Reasons That Older Adults are Unable to Identify a Healthcare Agent.

Journal of the American Geriatrics Society·2026
Same journal

Assigning Probable Dementia Status Using Routinely Collected Electronic Health Record Data.

Journal of the American Geriatrics Society·2026
Same journal

Caregiver Burden at the Onset of Acute Hospital-At-Home.

Journal of the American Geriatrics Society·2026
Same journal

Utilization Patterns Among Heterogeneous Subgroups of Homebound Older Adults: A Latent Class Analysis.

Journal of the American Geriatrics Society·2026
See all related articles

Related Experiment Video

Updated: Jul 13, 2025

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

16.4K

Successful aging after elective surgery II: Study cohort description.

Michelle Ward1, Tammy T Hshieh2,3,4, Eva M Schmitt2

  • 1Division of General Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.

Journal of the American Geriatrics Society
|October 12, 2023
PubMed
Summary
This summary is machine-generated.

The SAGES II study enrolled 420 older adults undergoing surgery, collecting data on cognitive health and biomarkers. This research provides a foundation for understanding delirium and dementia risk after surgery.

Keywords:
biomarkerscognitive declinecognitive impairmentdeliriumdementialong-term cognitive decline

More Related Videos

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

2.7K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

572

Related Experiment Videos

Last Updated: Jul 13, 2025

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
08:17

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Published on: February 27, 2018

16.4K
The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

2.7K
Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles
04:00

Author Spotlight: Assessing Surgical Frailty with Point-of-Care Ultrasound of Quadriceps Muscles

Published on: July 26, 2024

572

Area of Science:

  • Gerontology
  • Neuroscience
  • Surgical Outcomes

Background:

  • The Successful Aging after Elective Surgery (SAGES) II Study investigates the link between delirium and Alzheimer's disease and related dementias (AD/ADRD).
  • The study captures novel fluid biomarkers, neuroimaging, and neurophysiological measurements in older adults undergoing surgery.
  • Understanding these relationships is crucial for improving cognitive health outcomes in aging populations.

Purpose of the Study:

  • To provide a comprehensive description of the SAGES II cohort, including baseline characteristics and data completion rates.
  • To detail modifications made to the study protocol due to the COVID-19 pandemic.
  • To establish a foundation for future research utilizing the SAGES II cohort.

Main Methods:

  • A prospective observational cohort study involving community-dwelling adults aged 65 and older undergoing major non-cardiac surgery.
  • Participants were assessed preoperatively, during hospitalization, and at 1, 2, 6, 12, and 18 months post-discharge.
  • Modified procedures, including video assessments, were implemented to maintain data quality during the COVID-19 pandemic.

Main Results:

  • Approximately 420 participants were enrolled, with a mean age of 73.4 years; 14% were from minority backgrounds.
  • 88% of participants underwent total knee or hip replacement surgery.
  • Despite pandemic challenges, high data completion rates were achieved, with nearly 90% completing interviews up to 6-month follow-up.

Conclusions:

  • The SAGES II study is unique in its focus on surgical outcomes and risk factors for delirium using novel biomarkers.
  • This paper presents the first description of the SAGES II cohort and its collected data.
  • The study provides a valuable resource for future research on aging, surgery, and cognitive decline.