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Updated: Jul 13, 2025

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Deep brain stimulation for psychostimulant use disorders.

Sarah E Swinford-Jackson1, R Christopher Pierce2

  • 1Brain Health Institute and Department of Psychiatry, Rutgers University, 683 Hoes Lane West Room 160, Piscataway, NJ, 08854-5635, USA. sarah.jackson@rutgers.edu.

Journal of Neural Transmission (Vienna, Austria : 1996)
|October 12, 2023
PubMed
Summary

Deep brain stimulation (DBS) shows promise for treating severe psychostimulant use disorders, specifically cocaine and methamphetamine addiction. Further research is needed to address limitations, including the lack of female participants in current studies.

Keywords:
CocaineDeep brain stimulationMethamphetamineNucleus accumbensSubstance use disorders

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Medical Technology

Background:

  • Effective treatments for psychostimulant use disorders are limited.
  • Deep brain stimulation (DBS) is FDA-approved for other conditions and shows potential for substance use disorders.

Purpose of the Study:

  • To review clinical and preclinical evidence for DBS targeting the nucleus accumbens for cocaine and methamphetamine use disorders.
  • To identify limitations in current research, such as the underrepresentation of females.

Main Methods:

  • Review of existing clinical and preclinical studies on DBS for psychostimulant use disorders.
  • Analysis of the efficacy of nucleus accumbens stimulation.

Main Results:

  • Evidence suggests DBS of the nucleus accumbens is a potential therapeutic strategy.
  • Current literature lacks studies including female participants.

Conclusions:

  • DBS of the nucleus accumbens warrants further investigation as a treatment for severe psychostimulant use disorders.
  • Future research should prioritize inclusivity and explore optimized brain stimulation techniques.