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Related Experiment Videos

Decreased bioavailable testosterone in aging normal and impotent men.

H R Nankin, J H Calkins

    The Journal of Clinical Endocrinology and Metabolism
    |December 1, 1986
    PubMed
    Summary

    Tissue available testosterone (T) decreases with age, particularly non-sex hormone-binding globulin-bound T (non-SHBG-T). This finding suggests non-SHBG-T is a sensitive indicator of age-related androgen decline.

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    Area of Science:

    • Endocrinology
    • Aging Research
    • Andrology

    Background:

    • Bioavailable testosterone (T) is crucial for physiological androgen activity.
    • Circulating T includes free T (FT) and albumin-bound T, but not SHBG-bound T.
    • Assessing bioavailable T requires measuring non-SHBG-bound T (non-SHBG-T).

    Purpose of the Study:

    • To evaluate bioavailable T levels in aging men.
    • To compare non-SHBG-T in young versus aged men.
    • To determine if non-SHBG-T is a sensitive marker for age-related androgen changes.

    Main Methods:

    • Serum samples from young (22-39 yr) and aged (65-83 yr) healthy men were analyzed.
    • Non-SHBG-T was precipitated using 50% ammonium sulfate.
    • Serum T, FT, LH, and non-SHBG-T levels were compared between age groups.

    Main Results:

    • Mean serum T, FT, and LH did not differ significantly between young and aged men.
    • Mean absolute non-SHBG-T was significantly lower in older men (P < 0.005).
    • In a separate cohort, non-SHBG-T was lower in middle-aged and elderly men compared to young men.

    Conclusions:

    • Tissue-available testosterone decreases in aging men.
    • Non-SHBG-T is a more sensitive indicator of age-related testosterone decline than total T or FT.
    • Androgen changes may begin by middle age.

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