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Updated: Jul 13, 2025

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo
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The Chemical Biology of NO that Regulates Oncogenic Signaling and Metabolism: NOS2 and Its Role in Inflammatory

Katrina M Miranda1, Lisa A Ridnour2, Robert Y S Cheng2

  • 1Department of Chemistry, University of Arizona, Tucson, Arizona.

Critical Reviews in Oncogenesis
|October 12, 2023
PubMed

Insights

Nitric oxide (NO) and its producing enzyme, nitric oxide synthase 2 (NOS2), play critical roles in cancer and inflammation. NO

Area of Science:

  • Biochemistry
  • Immunology
  • Oncology

Background:

  • Nitric oxide (NO) and nitric oxide synthase 2 (NOS2) are implicated in inflammation and cancer.
  • NOS2 expression in tumors shows varied correlations with patient prognosis.
  • The biological impact of NO is concentration-dependent, influencing specific cellular pathways.

Purpose of the Study:

  • To review the chemical reactions of NO and related species.
  • To discuss how these reactions relate to oncogenic and immunological signaling in cancer.
  • To elucidate the mechanisms by which NO influences cancer outcomes.

Main Methods:

  • Literature review of NO and NOS2 roles in cancer.
  • Analysis of NO reaction kinetics and biological outcomes.
  • Discussion of oncogenic and immunological pathways modulated by NO.

Main Results:

  • NO concentration critically determines pathway activation and biological outcomes.
  • Specific oncogenic and immunological mechanisms are activated by NO.
  • Reaction kinetics dictate the mechanisms of NO action in cancer.

Conclusions:

  • NO and NOS2 are pivotal in cancer-related inflammation and immune responses.
  • Understanding NO's concentration-dependent chemistry is key to predicting cancer prognosis.
  • NO's dual role in cancer necessitates detailed study of its reaction kinetics and signaling pathways.

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