Related Experiment Video

Updated: Jul 6, 2026

Non-invasive Assessment of Microvascular and Endothelial Function
05:41

Non-invasive Assessment of Microvascular and Endothelial Function

Published on: January 29, 2013

Arterial hemodynamics in human hypertension

C T Ting, K P Brin, S J Lin

    The Journal of Clinical Investigation
    |December 1, 1986
    PubMed

    Insights

    Hypertension is linked to higher aortic impedance, including increased resistance and reflections. Vasodilatation normalized these differences, suggesting increased vasomotor tone contributes to hypertension.

    Area of Science:

    • Cardiovascular Physiology
    • Hypertension Research
    • Hemodynamics

    Background:

    • Aortic impedance differences between normotensive and hypertensive individuals are not well understood.
    • Essential hypertension is characterized by complex hemodynamic alterations.

    Purpose of the Study:

    • To investigate and characterize aortic impedance parameters in hypertensive versus normotensive patients.
    • To explore the impact of vasodilatation and beta-blockade on these hemodynamic differences.

    Main Methods:

    • Cardiac catheterization was performed on 8 normotensive and 11 hypertensive Chinese patients.
    • Measurements were taken at rest, during nitroprusside administration, and handgrip exercise, before and after propranolol (beta blockade).

    Main Results:

    • Hypertensives exhibited significantly higher resistance, characteristic impedance, total external power, peripheral reflections, and first zero crossing of impedance phase angle.
    • Vasodilatation with nitroprusside normalized these abnormal impedance parameters.
    • Beta blockade (propranolol) increased resistance and reflections in both groups.

    Conclusions:

    • Hemodynamic abnormalities in essential hypertension, including increased resistance and reflections, are associated with elevated vasomotor tone.
    • This increased tone is further revealed by beta-blockade and can be reversed by vasodilatation.

    More Related Videos

    Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension09:40

    Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension

    Published on: April 11, 2016

    Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS08:12

    Invasive Hemodynamic Monitoring of Aortic and Pulmonary Artery Hemodynamics in a Large Animal Model of ARDS

    Published on: November 26, 2018

    Related Concept Videos

    Blood Pressure01:30

    Blood Pressure

    Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
    The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the diastolic...
    Special considerations while measuring blood pressure01:28

    Special considerations while measuring blood pressure

    When assessing blood pressure (BP), healthcare professionals must consider various factors and potential unexpected outcomes to ensure accurate readings and provide proper patient care. Adhering to these guidelines is essential to achieving the most reliable results.
    Monitoring Both Arms:
    Monitoring BP in both arms during the initial assessment is advisable, as the systolic value may differ by five to ten mm Hg between arms. For subsequent BP assessments, use the arm with the higher reading.
    Hypertension and Regulation of Blood Pressure01:18

    Hypertension and Regulation of Blood Pressure

    Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
    Blood Pressure01:24

    Blood Pressure

    The movement of blood in a human body, commonly referred to as blood flow, is determined by the volume of blood that traverses a certain section of the bodily system per unit time. It is the rhythmic contraction of the heart's ventricles that primarily instigates this movement. As the ventricles contract, blood is forced into the prominent arteries, which then flow from areas of greater pressure to lower pressure areas. This movement continues into smaller arteries and arterioles and...
    Hypertension II: Pathophysiology01:29

    Hypertension II: Pathophysiology

    Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
    Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

    Hypertension III: Clinical Manifestations and Diagnostic Studies

    Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...