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Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
Published on: January 5, 2016
Immune Responses in Controllers of HIV Infection
Abena K Kwaa1, Joel N Blankson1
1Center for AIDS Research, Department of Medicine, Johns Hopkins Medicine, Baltimore, Maryland, USA; email: kwaa.abena@gmail.com, jblanks@jhmi.edu.
Abstract:
Elite controllers are a heterogeneous group of people living with HIV who control viral replication without antiretroviral therapy. There is substantial evidence that at least some elite controllers are infected with replication-competent virus, thus they may serve as a model of a functional cure of HIV. The mechanisms responsible for virologic control have been actively studied. The most objective data support CD8+ T cell-based mechanisms of control, but other immune responses, mediated by antibodies and natural killer cells, may also play a role in controlling viral replication. In this article, we review the evidence for different mechanisms of immune control in these remarkable individuals.
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