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Precision Approaches to Chronic Obstructive Pulmonary Disease Management
Matthew Moll1,2,3,4, Edwin K Silverman1,2,4
1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA; email: matthew.moll@channing.harvard.edu, ed.silverman@channing.harvard.edu.
Annual Review of Medicine
|October 12, 2023
Summary
Precision medicine can overcome the challenges of chronic obstructive pulmonary disease (COPD) heterogeneity. Identifying high-risk patients and tailoring treatments based on individual factors will improve outcomes.
Area of Science:
- Pulmonary Medicine
- Genetics
- Pharmacology
Background:
- Chronic obstructive pulmonary disease (COPD) is a major global health burden causing significant morbidity and mortality.
- The inherent heterogeneity of COPD complicates the development of effective pharmacotherapies that can alter disease progression.
- A critical need exists to identify patients at high risk for adverse outcomes and understand the underlying mechanisms of this risk.
Purpose of the Study:
- To explore the potential of precision medicine approaches in addressing COPD heterogeneity.
- To highlight the importance of individualizing COPD management based on pathobiology, environmental factors, and psychosocial elements.
- To emphasize the need for mechanistic understanding of risk factors contributing to poor COPD outcomes.
Main Methods:
- Utilizing genetics, omics (genomics, proteomics, metabolomics, etc.), and network analytic techniques to dissect COPD heterogeneity.
- Investigating drug repurposing strategies informed by specific inflammatory biomarkers, such as type 2 inflammation.
- Leveraging large datasets and advanced analytical methods to identify patient subgroups.
Main Results:
- Genetics, omics, and network analysis are beginning to reveal specific pathobiologies within COPD.
- Drug repurposing based on biomarkers for conditions like type 2 inflammation shows promise for targeted therapies.
- Emerging analytical approaches facilitate the identification of individuals at high risk for poor COPD outcomes.
Conclusions:
- Precision medicine offers a promising avenue for managing COPD by tailoring treatments to individual pathophysiological profiles.
- These approaches hold significant potential for improving risk stratification, enabling early interventions, and facilitating drug repurposing in COPD.
- Further advancements in data analysis and omics technologies will enhance the ability to develop novel therapeutic strategies for COPD patients.
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