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Lipidomic analysis identified potential predictive biomarkers of statin response in subjects with Familial

Alvaro Cerda1, Raul Hernandes Bortolin2, Marcos Yukio Yoshinaga3

  • 1Department of Basic Sciences, Center of Excellence in Translational Medicine, CEMT-BIOREN, Universidad de La Frontera, Temuco 4810296, Chile.

Chemistry and Physics of Lipids
|October 12, 2023
PubMed

Insights

Familial hypercholesterolemia (FH) patients show altered lipid profiles with statin treatment. Phosphatidyl-inositol molecules (PI) are identified as key biomarkers predicting statin response in FH individuals.

Area of Science:

  • Biochemistry
  • Metabolomics
  • Cardiovascular Medicine

Background:

  • Familial hypercholesterolemia (FH) is a genetic lipid metabolism disorder leading to elevated LDL-c and premature atherosclerosis.
  • Statins are crucial for lowering LDL-c and preventing cardiovascular events by inhibiting cholesterol synthesis.

Purpose of the Study:

  • To investigate the impact of statin therapy on the serum lipidomic profile in FH patients.
  • To identify potential biomarkers that predict an individual's response to statin treatment.

Main Methods:

  • Seventeen adult FH patients were treated with atorvastatin or rosuvastatin after a washout period.
  • Serum lipidomic profiles were analyzed using ultra-high-performance liquid chromatography-tandem mass spectrometry.
  • Data analysis was performed using MetaboAnalyst v5.0 to identify significant lipid changes and predictive biomarkers.

Main Results:

  • Statin treatment significantly altered 8 out of 13 lipid classes, notably reducing phosphatidylinositols (PI) and triacylglycerols (TAG).
  • Specific PI molecules, including PI 16:0/18:2, 18:0/18:1, and 18:0/18:2, were significantly altered.
  • PI 16:1/18:0, 16:0/18:2, and 18:0/18:2 were identified as potent predictors of statin response, with high ROC AUC values.

Conclusions:

  • Statins profoundly modulate the serum lipid composition in individuals with FH.
  • Phosphatidyl-inositol (PI) molecules show promise as predictive biomarkers for statin efficacy in FH patients.

Keywords:
BiomarkersFamilial hypercholesterolemiaLipid-lowering drugsLipidomicsPhosphatidyl-inositolStatin

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