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The world apheresis association registry, 2023 update
Hans Vrielink1, Kaatje Le Poole1, Bernd Stegmayr2
1Unit of Transfusion medicine of Sanquin Blood Supply, Sanquin Blood Supply Foundation in Amsterdam, the Netherlands.
Summary
The WAA apheresis registry reports on over 58,000 procedures across 27 centers, showing diverse therapeutic apheresis (TA) uses, primarily stem cell collection for multiple myeloma. Adverse events were infrequent, with most being mild to moderate.
Area of Science:
- Hematology
- Nephrology
- Oncology
Background:
- The World Apheresis Association (WAA) registry collects global data on apheresis procedures.
- Apheresis is a critical therapeutic option for various medical conditions.
Purpose of the Study:
- To provide an updated overview of apheresis indications, procedure types, and adverse events (AEs) from the WAA registry.
- To analyze trends in therapeutic apheresis (TA) from 2018-2022.
Main Methods:
- Data from 27 centers within the WAA registry, covering 9,500 patients and 58,355 apheresis procedures (2018-2022).
- Analysis of procedure types, diagnoses, vascular access, anticoagulants, and reported adverse events.
Main Results:
- Stem cell collection was the most common procedure (51% for multiple myeloma).
- Plasma exchange (PEX) constituted 28% of procedures, with TTP as the main indication.
- Adverse events occurred in 2.7% of procedures, predominantly mild (1%) or moderate (1.5%).
Conclusions:
- Apheresis procedures exhibit a broad range of indications and procedural variations.
- The WAA registry data indicate a low frequency of adverse events associated with therapeutic apheresis.
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