Related Experiment Video

Updated: Jul 13, 2025

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults
06:11

Employing the Forced Oscillation Technique for the Assessment of Respiratory Mechanics in Adults

Published on: February 9, 2022

5.6K

Childhood TB sequel: evaluating respiratory function after treatment for pulmonary tuberculosis in a prospective

Esin Nkereuwem1,2, Schadrac Agbla3,4, Muhammed Lamin Jatta5

  • 1Vaccines and Immunity Theme, MRC Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Fajara, The Gambia. esin.nkereuwem@lshtm.ac.uk.

BMC Pulmonary Medicine
|October 12, 2023
PubMed

Insights

Tuberculosis (TB) can cause lasting lung damage in children, even after successful treatment. The Childhood TB Sequel study investigates these post-TB lung disease (PTLD) consequences and risk factors in Gambian children.

Area of Science:

  • Pediatric pulmonology
  • Infectious diseases
  • Global health

Background:

  • Tuberculosis (TB) affects 1.2 million children globally each year, with 85% achieving treatment success.
  • However, successful TB treatment often results in long-term lung damage, known as post-TB lung disease (PTLD).
  • Limited data exists on the burden and progression of PTLD in pediatric populations.

Purpose of the Study:

  • To describe the respiratory consequences of pulmonary TB in Gambian children.
  • To track the evolution of these lung sequelae over time.
  • To identify epidemiological risk factors associated with PTLD in children.

Main Methods:

  • Recruitment of up to 80 children (aged ≤19 years) recently treated for pulmonary TB.
  • Data collection includes clinical assessments, chest X-rays, and comprehensive lung function tests.
  • Assessments are conducted at treatment completion, and at 6 and 12 months post-treatment.

Main Results:

  • This section is to be filled once the study results are available.

Conclusions:

  • The Childhood TB Sequel study aims to fill critical knowledge gaps regarding PTLD in children.
  • Findings will inform the development of post-TB evaluation and long-term follow-up strategies.
  • This research is crucial for improving the long-term health outcomes of childhood TB survivors.
Abstract

Keywords:
Childhood tuberculosisImpairmentLung diseasePost-tuberculosisSequelaeSpirometry

More Related Videos

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis07:27

Simplified Whole Body Plethysmography to Characterize Lung Function During Respiratory Melioidosis

Published on: February 24, 2023

3.3K
A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection10:10

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection

Published on: October 5, 2015

19.0K

Related Concept Videos

Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
184
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
244
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
343
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
247
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
146
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
348