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Emerging roles of the CIP2A-TopBP1 complex in genome integrity

Henning Ummethum1, Jiayi Li1, Michael Lisby1

  • 1Department of Biology, University of Copenhagen, Copenhagen 2200, Denmark.

NAR Cancer
|October 13, 2023
PubMed

Insights

Cancer-associated proteins CIP2A and TopBP1 (topoisomerase IIβ-binding protein 1) interact to maintain genome stability during cell division. This interaction is crucial for basal-like breast cancers and presents a potential therapeutic target.

Area of Science:

  • Molecular oncology
  • Cellular biology
  • Genomic stability

Background:

  • CIP2A inhibits the tumor suppressor protein phosphatase 2A.
  • CIP2A is a synthetic lethal interactor of BRCA1 and BRCA2.
  • CIP2A drives basal-like breast cancers.

Purpose of the Study:

  • Review the CIP2A-TopBP1 interaction.
  • Elucidate their role in maintaining genome integrity during mitosis.
  • Discuss their involvement in cancer and therapeutic potential.

Main Methods:

  • Literature review of existing studies on CIP2A and TopBP1.
  • Analysis of the functional interplay between CIP2A and TopBP1.
  • Examination of their roles in cancer pathogenesis.

Main Results:

  • CIP2A and TopBP1 (topoisomerase IIβ-binding protein 1) collaborate to ensure genome integrity during mitosis.
  • This interaction is implicated in the development of basal-like breast cancers.
  • TopBP1 acts as a scaffold protein with diverse roles in DNA replication, transcription, and repair.

Conclusions:

  • The CIP2A-TopBP1 interaction is critical for maintaining genomic stability.
  • Dysregulation of this interaction contributes to cancer development.
  • Targeting the CIP2A-TopBP1 axis offers a promising therapeutic strategy for cancer treatment.

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