Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

IL-6 secretion of CD4<sup>+</sup> T cells stimulated by LC3-positive extracellular vesicles in human epithelial ovarian cancer.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·2022

Same author

[Evaluation on the effects of an education program regarding the sedentary behavior among school-aged children using Transtheoretical Model].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2011

Same author

[The application of near-infrared diffuse reflection spectra based on the principle of linear additive in tobacco redrying formula].

Guang pu xue yu guang pu fen xi = Guang pu·2011

Same author

Genetic study of families affected with aggressive periodontitis.

Periodontology 2000·2011

Same author

[Experimental study on Qi deficiency and blood stasis induced by muti-factor stimulation in rats].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica·2011

Same author

Improved visible light photocatalytic activity of sphere-like BiOBr hollow and porous structures synthesized via a reactable ionic liquid.

Dalton transactions (Cambridge, England : 2003)·2011

Search research articles

Related Experiment Video

Updated: Jul 13, 2025

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

Association between gut microbiota and endometriosis: a two-sample Mendelian randomization study.

Xuan Ji¹, Qi Yang¹, Xiu-Lin Zhu²

¹Medical School of Southeast University, Nanjing, Jiangsu Province, China.

Frontiers in Microbiology

|October 13, 2023

Summary

This study used Mendelian randomization to investigate gut microbiota (GM) and endometriosis (EMS) links. Eight GM taxa were associated with EMS risk, offering potential diagnostic and therapeutic insights.

Keywords:

Mendelian randomization analysis endometriosis genome-wide association study gut microbiota instrumental variables

More Related Videos

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Murine Fecal Isolation and Microbiota Transplantation

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

Related Experiment Videos

Last Updated: Jul 13, 2025

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice

Published on: November 24, 2020

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Establishment of an Experimental Mouse Model of Endometrioma to Study its Related Infertility

Published on: April 5, 2024

Murine Fecal Isolation and Microbiota Transplantation

Murine Fecal Isolation and Microbiota Transplantation

Published on: May 26, 2023

Area of Science:

Genetics
Microbiology
Epidemiology

Background:

Emerging evidence suggests gut microbiota (GM) imbalances may not consistently correlate with endometriosis (EMS).
Further investigation is needed to clarify the complex relationship between GM and EMS.
A two-sample Mendelian randomization (MR) study was designed to explore these associations.

Purpose of the Study:

To investigate the causal relationship between gut microbiota composition and the risk of endometriosis.
To identify specific gut bacteria taxa associated with endometriosis development.
To explore potential biomarkers for endometriosis diagnosis and novel therapeutic targets.

Main Methods:

Utilized a two-sample Mendelian randomization (MR) approach employing genome-wide association study (GWAS) summary statistics.
Leveraged the MiBioGen microbiota GWAS (N=18,340) for exposure data and the FinnGen study GWAS (8,288 EMS cases, 68,969 controls) for outcome data.
Applied the inverse variance weighted (IVW) method for primary analysis and conducted sensitivity analyses (Cochrane's Q, MR-Egger intercept, leave-one-out) to ensure result robustness.

Main Results:

The MR analysis identified 8 gut microbiota taxa significantly associated with endometriosis risk.
Protective associations were observed for Class-Melainabacteria, Family-Ruminococcaceae, and Genus-Eubacteriumruminantium.
Increased risk of endometriosis was linked to Order-Bacillales, Family-Prevotellaceae, Genus-Anaerotruncus, Genus-Olsenella, and Genus-RuminococcaceaeUCG002.

Conclusions:

This MR study established associations between 8 gut microbiota taxa and endometriosis risk.
These identified taxa may serve as potential indirect diagnostic markers for endometriosis.
The findings offer novel perspectives for understanding endometriosis pathogenesis and developing targeted treatments.