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Updated: Jul 13, 2025

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Sporothioethers: deactivated alkyl citrates from the fungus Hypomontagnella monticulosa
Henrike Heinemann1, Kevin Becker1, Hedda Schrey2,3
1OCI, BMWZ, Leibniz University of Hannover Schneiderberg 38 30167 Hannover Germany russell.cox@oci.uni-hannover.de.
Abstract:
Submerged cultivation of Hypomontagnella monticulosa MUCL 54604 resulted in formation of a stereoisomeric mixture of new sulfur-containing sporothriolide derivatives named sporothioethers A and B. The presence of the 2-hydroxy-3-mercaptopropanoic acid moiety attenuates the antimicrobial activity in comparison to the precursor sporothriolide suggesting a detoxification mechanism. However, moderate effects on biofilms of Candida albicans and Staphylococcus aureus were observed for sporothriolide and sporothioethers A and B at concentrations below their MICs.
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