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Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
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Solvent-Induced Raynaud's Phenomenon.

Helena Rodrigues1, Catarina Reigota1, Carolina Teles1

  • 1Internal Medicine, Centro Hospitalar e Universitário de Coimbra, Coimbra, PRT.

Cureus
|October 13, 2023
PubMed
Summary
This summary is machine-generated.

Severe Raynaud's phenomenon (RP) in a young woman, initially unresponsive to standard treatments, significantly improved with continuous intravenous iloprost infusion. This case highlights a novel treatment approach for severe secondary RP, improving symptoms and capillaroscopic findings.

Keywords:
iloprostoccupational riskraynaud’s phenomenonsecondary raynaud’s phenomenonsolvent exposure

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Area of Science:

  • Vascular Medicine
  • Occupational Health

Background:

  • Raynaud's phenomenon (RP) is a vasospastic disorder triggered by cold or stress, classified as primary or secondary.
  • Secondary RP (SRP) is linked to underlying conditions, necessitating thorough investigation for causative factors.

Observation:

  • A young female presented with severe RP, trophic changes, and abnormal capillaroscopy.
  • Initial investigations revealed SRP attributed to solvent exposure.

Findings:

  • Standard treatments including calcium channel blockers, Vitamin C, and pentoxifylline showed limited efficacy.
  • Continuous intravenous iloprost infusion led to significant symptom improvement and normalized capillaroscopic findings.

Implications:

  • Continuous iloprost infusion represents a promising therapeutic strategy for severe, treatment-refractory secondary Raynaud's phenomenon.
  • Identifying and mitigating occupational exposures, such as solvents, is crucial in managing SRP.