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Association between chronic kidney disease and risk of bullous pemphigoid: a nationwide population-based cohort study

Wen-Ting Yu1,2, Sheng-Hsiang Ma1,3, Chun-Ying Wu4,5,6

  • 1Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.

Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG
|October 13, 2023
PubMed

Insights

Patients with chronic kidney disease (CKD) have an increased risk of developing bullous pemphigoid (BP). This risk is higher for those requiring dialysis, highlighting a significant association between kidney disease and BP.

Area of Science:

  • Nephrology
  • Dermatology
  • Epidemiology

Background:

  • Bullous pemphigoid (BP) is known to occur in patients with chronic kidney disease (CKD).
  • The precise risk of developing BP in CKD patients remains unclear.

Purpose of the Study:

  • To investigate the association between chronic kidney disease (CKD) and the risk of developing bullous pemphigoid (BP).

Main Methods:

  • A large-scale cohort study using Taiwan's National Health Insurance Database (2007-2018).
  • Included 637,664 CKD patients and 637,664 matched non-CKD controls.
  • A competing risk model analyzed the incidence of BP.

Main Results:

  • CKD significantly increases the risk of BP (aHR: 1.29; p < 0.001).
  • Dialysis-dependent CKD patients showed the highest BP risk (aHR: 1.75).
  • Non-dialysis CKD patients also had an elevated BP risk (aHR: 1.20).

Conclusions:

  • CKD is a significant risk factor for bullous pemphigoid.
  • Patients with dialysis-dependent CKD face a substantially higher risk of BP compared to non-CKD individuals.
Abstract

Keywords:
Bullous pemphigoidTaiwan's National Health Insurance Research Databasechronic kidney diseasecohort studydialysis

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