Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

3.7K
The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
3.7K
Microtubules in Signaling01:22

Microtubules in Signaling

1.7K
The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
1.7K
Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

256
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
256
Cystic Fibrosis: Management01:24

Cystic Fibrosis: Management

173
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
173
Microtubule Associated Motor Proteins01:32

Microtubule Associated Motor Proteins

8.1K
Eukaryotic cells have different motor proteins for transporting various cargo within the cell. These motor proteins differ based on the filament they associate with, the direction they move within the cell, and the type of cargo they transport. Motor proteins that associate with microtubules are known as microtubule-associated motor proteins. There are two families of microtubule-associated motor proteins —Kinesins and Dyneins. Both these proteins assist in the transport of cellular...
8.1K
Types of Intermediate Filaments01:31

Types of Intermediate Filaments

3.7K
The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Manganese-enhanced magnetic resonance assessment of changes in hippocampal neural function after the treatment of radiation-induced brain injury with bone marrow mesenchymal stem cells.

Brain research bulletin·2023
Same author

Molecular dynamics study of fluorosulfonyl ionic liquids as electrolyte for electrical double layer capacitors.

RSC advances·2023
Same author

Correction: Targeting ARHGEF12 promotes neuroblastoma differentiation, MYCN degradation, and reduces tumorigenicity.

Cellular oncology (Dordrecht, Netherlands)·2023
Same author

[The clinical value of recurrent laryngeal nerve dissection in the surgical treatment for congenital pyriform sinus fistula].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery·2023
Same author

Radiation-induced acoustic signal denoising using a supervised deep learning framework for imaging and therapy monitoring.

Physics in medicine and biology·2023
Same author

Integration of in-situ and ex-situ power-to-gas (PtG) strategy for simultaneous bio-natural gas production and CO<sub>2</sub> emission reduction.

Chemosphere·2023
Same journal

Multi-Omics Landscape of Paraspinal Muscles in Spinal Muscular Atrophy With Scoliosis.

Journal of cellular and molecular medicine·2026
Same journal

Overexpression of Circular RNA circTTN Promotes Ferroptosis in Sepsis-Induced Cardiomyopathy.

Journal of cellular and molecular medicine·2026
Same journal

PLOD1 Drives Head and Neck Squamous Cell Carcinoma Progression Through P4HA2-Mediated Activation of the FAK/PI3K/AKT/mTOR Axis.

Journal of cellular and molecular medicine·2026
Same journal

Valsartan Reduces Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferritinophagy-Mediated Ferroptosis.

Journal of cellular and molecular medicine·2026
Same journal

Metabolic Dysregulation of FC3 Fibrochondrocytes via MDH2 Promotes Intervertebral Disc Degeneration.

Journal of cellular and molecular medicine·2026
Same journal

PGK1 Drives Glial Glycolytic Reprogramming to Mediate Isoflurane-Induced Cognitive Impairment in Aged Mice.

Journal of cellular and molecular medicine·2026
See all related articles

Related Experiment Video

Updated: Jul 13, 2025

In vivo Evaluation of Mucociliary Clearance in Mice
06:35

In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

4.4K

Cilia-related diseases.

Zhanhong Ren1, Xiaoxiao Mao1,2, Siqi Wang1

  • 1Hubei Key Laboratory of Diabetes and Angiopathy, Medicine Research Institute, Xianning Medical College, Hubei University of Science and Technology, Xianning, P. R. China.

Journal of Cellular and Molecular Medicine
|October 13, 2023
PubMed
Summary
This summary is machine-generated.

Cilia are crucial for cell function, and their defects cause diseases like ciliopathy and primary ciliary dyskinesia (PCD). This review explores their characteristics, mechanisms, and treatments to advance research.

Keywords:
ciliaciliopathymotile ciliaprimary ciliaprimary ciliary dyskinesia

More Related Videos

Artificial Intelligence Approaches to Assessing Primary Cilia
08:58

Artificial Intelligence Approaches to Assessing Primary Cilia

Published on: May 1, 2021

3.5K
Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

9.4K

Related Experiment Videos

Last Updated: Jul 13, 2025

In vivo Evaluation of Mucociliary Clearance in Mice
06:35

In vivo Evaluation of Mucociliary Clearance in Mice

Published on: December 18, 2020

4.4K
Artificial Intelligence Approaches to Assessing Primary Cilia
08:58

Artificial Intelligence Approaches to Assessing Primary Cilia

Published on: May 1, 2021

3.5K
Using Primary Neurosphere Cultures to Study Primary Cilia
08:14

Using Primary Neurosphere Cultures to Study Primary Cilia

Published on: April 14, 2017

9.4K

Area of Science:

  • Cell Biology
  • Genetics
  • Medical Science

Background:

  • Cilia are vital cellular structures involved in various biological processes.
  • Abnormal cilia morphogenesis leads to diverse diseases, including ciliopathy and primary ciliary dyskinesia (PCD).
  • Primary cilia are increasingly recognized for their role in cardiovascular homeostasis, though underlying mechanisms are unclear.

Purpose of the Study:

  • To review recent advancements in understanding ciliopathy and PCD.
  • To elucidate the molecular mechanisms underlying cilia-related diseases.
  • To summarize current and potential treatment strategies for these conditions.

Main Methods:

  • Literature review of recent research on cilia-related diseases.
  • Analysis of studies focusing on ciliopathy and primary ciliary dyskinesia (PCD).
  • Synthesis of information on disease characteristics, molecular pathways, and therapeutic approaches.

Main Results:

  • Cilia-related diseases encompass a broad spectrum affecting multiple organs.
  • Defects in primary cilia cause ciliopathy, while motile cilia dysfunction leads to PCD.
  • Research highlights the critical role of primary cilia in cardiovascular health.

Conclusions:

  • Understanding cilia biology is essential for addressing complex human diseases.
  • Further research into molecular mechanisms is needed for effective treatment development.
  • This review provides a foundation for future studies on cilia-related disease pathogenesis and therapies.