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Updated: Jul 13, 2025

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Senescent Cells: Dual Implications on the Retinal Vascular System.

Mohammad Reza Habibi-Kavashkohie1,2, Tatiana Scorza1,2, Malika Oubaha1,2

  • 1Department of Biological Sciences, Université du Québec à Montréal (UQAM), Montréal, QC H2L 2C4, Canada.

Cells
|October 13, 2023
PubMed
Summary

Cellular senescence, a permanent cell cycle arrest, impacts retinal vascular development and disease. Senolytics and senomorphics offer potential therapeutic strategies for age-related retinal conditions.

Keywords:
cellular senescenceproliferative retinopathiesretinal vascular systemsenescence-associated secretory phenotype (SASP)senotherapeutic agents

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Area of Science:

  • Ophthalmology
  • Gerontology
  • Cell Biology

Background:

  • Cellular senescence is a state of irreversible cell cycle arrest.
  • Senescent cells accumulate in the retina with age and stress.
  • The senescence-associated secretory phenotype (SASP) contributes to inflammation and tissue dysfunction.

Purpose of the Study:

  • To review the mechanisms of cellular senescence.
  • To explore the dual role of senescent cells in retinal vascular development and disease.
  • To discuss senotherapeutic strategies for retinal conditions.

Main Methods:

  • Literature review of cellular senescence mechanisms.
  • Analysis of senescent cell involvement in retinal vascularization.
  • Examination of senolytic and senomorphic therapies.

Main Results:

  • Senescent cells play beneficial roles in embryogenesis and tissue repair.
  • Senescent cells contribute to both retinal vascular development and proliferative retinopathies.
  • The SASP from senescent cells exacerbates retinal pathologies.

Conclusions:

  • Cellular senescence has complex effects on retinal vasculature.
  • Targeting senescent cells offers potential therapeutic avenues for retinal diseases.
  • Senolytics and senomorphics are promising senotherapeutic strategies.