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Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
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Senescent Cells: Dual Implications on the Retinal Vascular System
Mohammad Reza Habibi-Kavashkohie1,2, Tatiana Scorza1,2, Malika Oubaha1,2
1Department of Biological Sciences, Université du Québec à Montréal (UQAM), Montréal, QC H2L 2C4, Canada.
Cells
|October 13, 2023
Summary
Cellular senescence, a permanent cell cycle arrest, impacts retinal vascular development and disease. Senolytics and senomorphics offer potential therapeutic strategies for age-related retinal conditions.
Area of Science:
- Ophthalmology
- Gerontology
- Cell Biology
Background:
- Cellular senescence is a state of irreversible cell cycle arrest.
- Senescent cells accumulate in the retina with age and stress.
- The senescence-associated secretory phenotype (SASP) contributes to inflammation and tissue dysfunction.
Purpose of the Study:
- To review the mechanisms of cellular senescence.
- To explore the dual role of senescent cells in retinal vascular development and disease.
- To discuss senotherapeutic strategies for retinal conditions.
Main Methods:
- Literature review of cellular senescence mechanisms.
- Analysis of senescent cell involvement in retinal vascularization.
- Examination of senolytic and senomorphic therapies.
Main Results:
- Senescent cells play beneficial roles in embryogenesis and tissue repair.
- Senescent cells contribute to both retinal vascular development and proliferative retinopathies.
- The SASP from senescent cells exacerbates retinal pathologies.
Conclusions:
- Cellular senescence has complex effects on retinal vasculature.
- Targeting senescent cells offers potential therapeutic avenues for retinal diseases.
- Senolytics and senomorphics are promising senotherapeutic strategies.
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