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Author Spotlight: Advancements in Understanding and Combatting Shigella Infections
Published on: February 9, 2024
Genomic, transcriptomic, and phenotypic differences among archetype Shigella flexneri strains of serotypes 2a, 3a,
Caitlin E Gabor1,2,3, Tracy H Hazen1,2, BreOnna C Delaine-Elias3
1Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Importance:
Given the genomic diversity between S. flexneri serotypes and the paucity of data to support serotype-specific phenotypic differences, we applied in silico and in vitro functional analyses of archetype strains of 2457T (Sf2a), J17B (Sf3a), and CH060 (Sf6). These archetype strains represent the three leading S. flexneri serotypes recommended for inclusion in multivalent vaccines. Characterizing the genomic and phenotypic variation among these clinically prevalent serotypes is an important step toward understanding serotype-specific host-pathogen interactions to optimize the efficacy of multivalent vaccines and therapeutics. This study underpins the importance for further large-scale serotype-targeted analyses.
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