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Related Experiment Videos

Recurrent oral ulceration treated with Mysteclin: a controlled study.

A M Denman, A A Schiff

    British Medical Journal
    |May 12, 1979
    PubMed
    Summary
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    Mysteclin syrup, containing tetracycline hydrochloride and amphotericin, significantly reduced recurrent oral ulceration compared to placebo. This mouthwash provided lasting relief for oral ulcers without systemic side effects.

    Area of Science:

    • Oral Medicine
    • Pharmacology
    • Infectious Diseases

    Background:

    • Recurrent oral ulceration presents a significant clinical challenge.
    • Current treatments may have limitations or adverse effects.

    Purpose of the Study:

    • To evaluate the efficacy of Mysteclin syrup (tetracycline hydrochloride and amphotericin) as a mouthwash for recurrent oral ulceration.

    Main Methods:

    • A placebo-controlled, double-blind trial involving twenty patients with recurrent oral ulceration.
    • Mysteclin syrup was administered as a mouthwash.
    • Outcomes measured included reduction in ulcer scores and new ulcer formation.

    Main Results:

    • A significant reduction in mean pair scores and daily new ulcers was observed with Mysteclin syrup compared to placebo.

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  • The therapeutic effect persisted for at least four weeks post-treatment.
  • No adverse systemic effects were reported.

    • Conclusions:

    • Mysteclin syrup is an effective mouthwash for managing recurrent oral ulceration.
    • Unlike topical steroids, its efficacy is not stage-dependent and it lacks systemic side effects.