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IL-31-dependent neurogenic inflammation restrains cutaneous type 2 immune response in allergic dermatitis

Marlys S Fassett1,2,3, Joao M Braz4, Carlos A Castellanos2,3

  • 1Department of Dermatology, University of California, San Francisco, CA, USA.

Science Immunology
|October 13, 2023
PubMed
Summary

Interleukin-31 (IL-31) limits skin inflammation by activating neuroimmune pathways. Disrupting IL-31 exacerbates allergic dermatitis, revealing its role in regulating immune responses.

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