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Updated: Jul 13, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators

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Unveiling Mechanical Activation: GAIN Domain Unfolding and Dissociation in Adhesion GPCRs

Chaoyu Fu1,2, Wenmao Huang1,2, Qingnan Tang1

  • 1Department of Physics, National University of Singapore, Singapore 117551, Singapore.

Nano Letters
|October 13, 2023
PubMed

Keywords:
BAI3GAIN domain dissociationGAIN domain unfoldingGPR56LPHN1adhesion GPCR

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