Determination of the Toxicity Preferences of Ocular Drug Delivery System by Comparing Two Different Toxicity
Burcu Uner1,2,3, Meltem Ezgi Durgun4, Samet Ozdemir5
1Department of Pharmaceutical Technology, Institute of Graduate Studies in Health Sciences, Istanbul University, Istanbul, Turkey.
Abstract:
Ocular drug delivery methods are highly favored for boosting bioavailability, patient compliance, and lower adverse effects and dose frequency. In addition to preventing adverse effects from the active ingredient, the parts of drug delivery systems must be nontoxic and nonallergic as well. Mitochondrial toxicity test (MTT) and Hen's egg chorioallantois membrane (HET-CAM) assay are the most often utilized tests based on this dilemma. The toxicity of loteprednol etabonate loaded solid lipid nanoparticles, lipid nanostructured carriers, and nanoemulsion were compared. Oleic acid, Precirol.
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