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Functioning oncocytic adenoma of the pituitary
Journal of Neuro-Oncology
|January 1, 1986
Summary
This case report details a rare functioning invasive pituitary oncocytoma. The tumor, positive for prolactin, showed abnormal mitochondria and secretorily active cells.
Area of Science:
- Endocrinology
- Oncology
- Cell Biology
Background:
- Pituitary oncocytomas are rare tumors, typically non-functioning.
- Functioning pituitary adenomas can cause hormonal imbalances.
Observation:
- A 50-year-old male presented with a functioning invasive pituitary oncocytoma.
- Elevated serum prolactin levels and positive immunocytochemical staining for prolactin were noted.
- Neoplastic cells contained numerous mitochondria, some with abnormal crystalline inclusions.
Findings:
- The tumor exhibited approximately 10-15% non-oncocytic cells with prominent rough endoplasmic reticulum (RER) and Golgi apparatus.
- These secretorily active cells are hypothesized to be responsible for the tumor's functional activity.
- The presence of abnormal mitochondria suggests unique cellular pathology.
Implications:
- This case expands the understanding of pituitary oncocytoma subtypes.
- It highlights the potential for oncocytomas to exhibit hormonal activity.
- Further research into the cellular mechanisms of functioning pituitary tumors is warranted.