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Comprehensive DNA Methylation Analysis Using a Methyl-CpG-binding Domain Capture-based Method in Chronic Lymphocytic Leukemia Patients
Published on: June 16, 2017
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Epigenomic Characterization of Lymphoid Neoplasms
Martí Duran-Ferrer1, José Ignacio Martín-Subero1,2,3
1Institut d'Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), Barcelona, Spain;
Annual Review of Pathology
|October 13, 2023
Summary
Lymphoid neoplasms exhibit significant epigenomic changes, including DNA methylation alterations, that reflect their cellular origin and history. These epigenetic modifications offer valuable diagnostic and therapeutic insights for these complex diseases.
Area of Science:
- Oncology
- Genetics
- Epigenetics
Background:
- Lymphoid neoplasms are diverse diseases with genetic and epigenomic alterations.
- Epigenomic changes impact DNA methylation, histone modifications, and chromatin structure.
Purpose of the Study:
- To explore the role of epigenomic changes in lymphoid neoplasms.
- To highlight the clinical applications of epigenetics in lymphoma.
Main Methods:
- Analysis of DNA methylation patterns and epigenetic marks.
- Investigation of chromatin accessibility and 3D genome interactions.
- Single-cell profiling for intraclonal heterogeneity.
Main Results:
- Epigenetic imprints in B cell neoplasms correlate with cellular origin and proliferation.
- Altered regulatory regions and transcription factor networks are identified.
- Epigenetic and genetic aberrations interact with the microenvironment to shape the transcriptome.
Conclusions:
- Epigenetics provides insights into lymphoid tumor development and evolution.
- Epigenetic biomarkers show potential for diagnosis and prognosis.
- Epigenetic modifications represent promising therapeutic targets in lymphoid cancers.
