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PAllidal versus SubThalamic deep brain Stimulation for Cervical Dystonia (PASTS-CD): study protocol for a multicentre
Bin Liu1,2, Junpeng Xu1,2, Haonan Yang1,2
1Medical School, Chinese PLA General Hospital, Beijing, China.
This study compares deep brain stimulation (DBS) targeting the globus pallidus internus (GPi) versus the subthalamic nucleus (STN) for cervical dystonia (CD). It aims to determine the optimal DBS target for improved patient outcomes and safety.
Area of Science:
- Neurology
- Neurosurgery
- Clinical Trials
Background:
- Refractory cervical dystonia (CD) is a debilitating condition.
- Deep brain stimulation (DBS) is a validated treatment for CD.
- Current DBS practice uses either globus pallidus internus (GPi) or subthalamic nucleus (STN) targets, but optimal target selection remains unclear.
Purpose of the Study:
- To directly compare the efficacy and safety of GPi-DBS versus STN-DBS in patients with refractory CD.
- To provide evidence-based guidance for selecting the optimal DBS target in clinical practice for CD.
Main Methods:
- A multicenter, prospective, randomized, controlled study enrolling 98 refractory CD patients.
- Patients randomly assigned to GPi-DBS or STN-DBS.
- Primary outcome: improvement in symptom severity (TWSTRS and Tsui scales) at 3, 6, and 12 months post-surgery.
Main Results:
- This section is to be filled after the study's completion.
Conclusions:
- This section is to be filled after the study's completion.
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