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Related Experiment Video

Updated: Jul 13, 2025

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Quantification of Vascular Parameters in Whole Mount Retinas of Mice with Non-Proliferative and Proliferative Retinopathies

Published on: March 12, 2022

Folate and retinal vascular diseases.

Jinyue Gu^1,2, Chunyan Lei^1,2, Meixia Zhang^3,4

¹Department of Ophthalmology, West China Hospital, Sichuan University, 610041, Chengdu, China.

BMC Ophthalmology

|October 13, 2023

Summary

Folic acid supplementation may help protect against retinal vascular diseases by lowering homocysteine levels. This review suggests potential benefits for patients with high homocysteine or glucose status.

Keywords:

Age-related macular degeneration Diabetic retinopathy Folate Homocysteine Retinal vascular occlusions

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Last Updated: Jul 13, 2025

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Isolation of Primary Mouse Retinal Pigmented Epithelium Cells

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Published on: November 4, 2022

Area of Science:

Ophthalmology
Nutritional Science
Cardiovascular Science

Background:

Elevated homocysteine and low folate are linked to retinal vascular diseases.
Hyperhomocysteinemia is a risk factor for cardiovascular issues.
Homocysteine may cause vascular endothelial cell toxicity.

Purpose of the Study:

To review findings on folate and retinal vascular diseases.
To assess the potential of folic acid supplementation as a treatment.

Main Methods:

Literature review of studies on folate, homocysteine, and retinal vascular diseases.
Analysis of in vitro data on folic acid and endothelial cells.

Main Results:

Folate deficiency is a common cause of high homocysteine.
Folic acid demonstrated protective effects on vascular cells in vitro.
Association between folate status, homocysteine, and retinal diseases is noted.

Conclusions:

Folic acid supplementation may offer a protective strategy for retinal vascular diseases.
Patients with high homocysteine or glucose may benefit from folic acid.
Further research is required to confirm the therapeutic efficacy of folate.