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Published on: September 30, 2021
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Urinary biomarkers for hepatocellular carcinoma: current knowledge for clinicians
Kaige Deng1, Jiali Xing1, Gang Xu2
1Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China.
Cancer Cell International
|October 14, 2023
Summary
Hepatocellular carcinoma (HCC), a deadly liver cancer, is hard to detect early. Urine biomarkers show promise for improving diagnosis and treatment, offering new tools for precision medicine.
Area of Science:
- Hepatology and Oncology
- Biomarker Discovery
- Molecular Diagnostics
Background:
- Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality globally.
- Its aggressive nature and late diagnosis contribute to poor patient outcomes.
- The complex pathogenesis of HCC hinders effective therapeutic development.
Purpose of the Study:
- To review and assess the clinical potential of urinary biomarkers for HCC.
- To explore novel diagnostic, prognostic, and monitoring tools for HCC.
- To evaluate the applicability of urine-based markers in precision medicine for liver cancer.
Main Methods:
- Comprehensive literature review of studies on urinary biomarkers for HCC.
- Analysis of diverse molecular types, testing platforms, and multimolecule modeling approaches.
- Assessment of the clinical utility and potential for transformation of identified biomarkers.
Main Results:
- Urinary biomarkers offer a promising avenue for HCC detection and management.
- A wide array of molecular targets and detection methods are being explored.
- Diverse strategies for multimolecule model development exist, enhancing potential applications.
Conclusions:
- Urine biomarkers represent a valuable supplement to current HCC diagnostic tools like alpha-fetoprotein (AFP).
- The heterogeneity in study designs provides a rich toolkit for future clinical translation.
- These biomarkers hold significant potential for advancing precision medicine in HCC management.
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