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Updated: Jul 13, 2025
08:25
Identification of Circular RNAs using RNA Sequencing
Published on: November 14, 2019
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The Glioblastoma CircularRNAome.
Alexandru Tirpe1,2, Cristian Streianu2, Stefana Maria Tirpe3
1Research Center for Functional Genomics, Biomedicine and Translational Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 23 Marinescu Street, 400337 Cluj-Napoca, Romania.
International Journal of Molecular Sciences
|October 14, 2023
Summary
Circular RNAs (circRNAs) show significant roles in glioblastoma, impacting cancer progression and treatment resistance. These molecules are promising biomarkers and therapeutic targets for aggressive brain tumors.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Glioblastoma is an aggressive brain cancer needing better diagnostic and treatment strategies.
- Circular RNAs (circRNAs) are stable RNA molecules with diverse regulatory functions, including microRNA sponging and protein interaction.
Purpose of the Study:
- To critically review glioblastoma-associated circRNAs.
- To elucidate the roles of circRNAs in glioblastoma progression and therapeutic resistance.
Main Methods:
- Literature review of glioblastoma-related circRNAs.
- Analysis of circRNA functions in cancer cell proliferation, survival, migration, invasion, metastasis, metabolic reprogramming, and drug resistance.
Main Results:
- Identified key circRNAs involved in glioblastoma pathogenesis.
- Highlighted circRNA regulation of critical oncogenic pathways like MAPK, PI3K/AKT/mTOR, and Wnt.
- Demonstrated circRNA influence on glioblastoma cell behaviors and therapeutic outcomes.
Conclusions:
- Circular RNAs play a significant role in glioblastoma development and progression.
- CircRNAs represent potential novel biomarkers for early diagnosis.
- CircRNAs offer promising therapeutic targets and agents for glioblastoma treatment.
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