Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs Acting on Autonomic Ganglia: Stimulants01:23

Drugs Acting on Autonomic Ganglia: Stimulants

1.4K

Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
1.4K
CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

221
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
221
Stimulants01:29

Stimulants

224
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
224
Cholinergic Receptors: Nicotinic01:15

Cholinergic Receptors: Nicotinic

2.9K
Nicotinic receptors are ligand-gated ion channels that are activated by acetylcholine and nicotine. Upon activation, they cause a rapid increase in the permeability of cells to K+, Na+, and Ca2+, followed by depolarization and excitation. They are in the autonomic ganglia, skeletal neuromuscular junction, CNS, and adrenal medulla.
There are two types of nicotinic receptors: neuromuscular (NM/NM/N1) and neuronal (NN/NN/N2). The two families differ based on their location and selectivity to...
2.9K
Drug Dependence01:17

Drug Dependence

1.0K
Medications are typically administered to achieve therapeutic effects. Some drugs can modify an individual's mood and perception, frequently resulting in various enjoyable experiences. However, this can result in drug dependency, a condition marked by continuous drug use despite potential negative consequences. Drug dependency primarily falls into two categories: psychological and physical dependence. Psychological dependence occurs when the pleasurable feelings induced by the drug...
1.0K
Drug Abuse and Addiction: Pharmacological Phenomena01:15

Drug Abuse and Addiction: Pharmacological Phenomena

489
Drug dependence, abuse, and addiction are complex phenomena that can precipitate various abnormal states. Physical dependence refers to a state of pharmacological adaptation to a drug. This adaptation often results in tolerance—a reduced response to the drug after repeated administrations. When the drug use is abruptly stopped, withdrawal symptoms occur due to the body's need to readjust from the pharmacologically induced imbalance. However, tolerance and withdrawal symptoms do not...
489

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Retraction Note: Gene and protein expression of CXCR4 in adult and elderly patients with chronic rhinitis, pharyngitis or sinusitis undergoing thermal water nasal inhalations.

Immunity & ageing : I & A·2026
Same author

Effects of Caloric Restriction on DNA Damage: A Comparison of Very Low-Calorie and Standard Reduced-Calorie Diets in Obesity-Non-Randomised, Quasi-Experimental Clinical Intervention Study.

Nutrients·2026
Same author

Nano- and Microplastics in the Cardiovascular System: Current Insights and Biological Implications.

Nanomaterials (Basel, Switzerland)·2026
Same author

TTV virome marks immune exhaustion, α7nAChR alteration, and mortality in elderly patients with severe COPD.

GeroScience·2026
Same author

Secondhand smoke and e-cigarette aerosol exposure in dogs and cats: A scoping review with implications for smoking cessation among pet owners.

Tobacco prevention & cessation·2026
Same author

The gut and circulating virome: emerging players in aging and longevity.

Frontiers in aging·2026

Related Experiment Video

Updated: Jul 13, 2025

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
08:47

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Published on: February 10, 2012

13.5K

Nicotine: From Discovery to Biological Effects.

Luigi Sansone1,2, Francesca Milani3, Riccardo Fabrizi3

  • 1Department of Human Sciences and Quality, Life Promotion San Raffaele University, Via di Val Cannuta 247, 00166 Rome, Italy.

International Journal of Molecular Sciences
|October 14, 2023
PubMed
Summary

Nicotine from tobacco causes addiction and affects mammalian cells, impacting health. Public health efforts must address smoking risks and nicotine

Keywords:
cardiovascular diseasescell proliferationcognitiondependencelung cancerneo-angiogenesisnicotinenicotinic receptortobacco

More Related Videos

Local Application of Drugs to Study Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices
10:04

Local Application of Drugs to Study Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices

Published on: October 29, 2012

19.3K
Live Imaging of Nicotine Induced Calcium Signaling and Neurotransmitter Release Along Ventral Hippocampal Axons
12:19

Live Imaging of Nicotine Induced Calcium Signaling and Neurotransmitter Release Along Ventral Hippocampal Axons

Published on: June 24, 2015

9.1K

Related Experiment Videos

Last Updated: Jul 13, 2025

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration
08:47

Spectral Confocal Imaging of Fluorescently tagged Nicotinic Receptors in Knock-in Mice with Chronic Nicotine Administration

Published on: February 10, 2012

13.5K
Local Application of Drugs to Study Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices
10:04

Local Application of Drugs to Study Nicotinic Acetylcholine Receptor Function in Mouse Brain Slices

Published on: October 29, 2012

19.3K
Live Imaging of Nicotine Induced Calcium Signaling and Neurotransmitter Release Along Ventral Hippocampal Axons
12:19

Live Imaging of Nicotine Induced Calcium Signaling and Neurotransmitter Release Along Ventral Hippocampal Axons

Published on: June 24, 2015

9.1K

Area of Science:

  • Pharmacology
  • Cell Biology
  • Public Health

Background:

  • Tobacco use is a global health issue, driven by nicotine, the primary psychoactive compound.
  • Nicotine exerts significant biological effects on mammalian cells, influencing various physiological processes.
  • Understanding these effects is crucial for public health policy and smoking cessation strategies.

Purpose of the Study:

  • To provide a historical overview of tobacco use.
  • To discuss nicotine dependence and its biological impacts on mammalian cells.
  • To highlight specific pathways, including those mediated by alpha-7 nicotinic receptors (α7 nAChRs).

Main Methods:

  • Literature review of historical tobacco use.
  • Analysis of biological effects of nicotine on mammalian cells.
  • Examination of cellular pathways influenced by nicotine and nicotinic receptors.

Main Results:

  • Nicotine induces neoangiogenesis, cell division, and proliferation.
  • Nicotine affects both neural and non-neural cells via pathways downstream of nicotinic receptors (nAChRs).
  • Specific effects mediated by α7 nAChRs were identified.

Conclusions:

  • Nicotine is highly addictive and poses significant health hazards.
  • Public health initiatives must focus on combating smoking and its associated risks.
  • Further research into nicotine's biological effects is essential for informed health policies and addressing global morbidity and mortality.