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Megakaryocyte Differentiation and Platelet Formation from Human Cord Blood-derived CD34+ Cells
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Platelets in Renal Disease

Drolma Gomchok1, Ri-Li Ge1,2, Tana Wuren1,2

  • 1Research Center for High Altitude Medicine, School of Medicine, Qinghai University, Xining 810001, China.

International Journal of Molecular Sciences
|October 14, 2023
PubMed

Kidney disease is a major global health concern, affecting millions of people. Nephrologists have shown interest in platelets because of coagulation disorders caused by renal diseases. With a better understanding of platelets, it has been found that these anucleate and abundant blood cells not only play a role in hemostasis, but also have important functions in inflammation and immunity. Platelets are not only affected by kidney disease, but may also contribute to kidney disease progression by mediating inflammation and immune effects. This review summarizes the current evidence regarding platelet abnormalities in renal disease, and the multiple effects of platelets on kidney disease progression. The relationship between platelets and kidney disease is still being explored, and further research can provide mechanistic insights into the relationship between thrombosis, bleeding, and inflammation related to kidney disease, and elucidate targeted therapies for patients with kidney disease.

Keywords:
hemostasisimmunityinflammationplateletsrenal disease

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