Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human melatonin production decreases with age.

R L Sack, A J Lewy, D L Erb

    Journal of Pineal Research
    |January 1, 1986
    PubMed
    Summary

    Melatonin production, measured by 6-hydroxymelatonin excretion, declines with age in humans. This study found no significant effect of season or other demographics on melatonin levels.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tuberculosis control in a socially vulnerable area: a community intervention beyond DOT in a Brazilian favela.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2013
    Same author

    Tooth-surface-specific effects of xylitol: randomized trial results.

    Journal of dental research·2013
    Same author

    Restricted spirometry in the Burden of Lung Disease Study.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2012
    Same author

    Efficacy of chlorhexidine varnish for the prevention of adult caries: a randomized trial.

    Journal of dental research·2011
    Same author

    Quality of spirometry tests performed by 9893 adults in 14 countries: the BOLD Study.

    Respiratory medicine·2011
    Same author

    Adolescent smokers are at greater risk for current asthma and rhinitis.

    The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2009

    Area of Science:

    • Endocrinology
    • Chronobiology
    • Human Physiology

    Background:

    • Melatonin is a key hormone regulating circadian rhythms.
    • Understanding factors influencing melatonin production is crucial for chronobiology research.
    • Previous studies suggest age and season may impact melatonin levels.

    Purpose of the Study:

    • To investigate the influence of season and demographic factors on melatonin production in healthy adults.
    • To quantify melatonin production by measuring 6-hydroxymelatonin (6-OHM) urinary excretion.

    Main Methods:

    • Collected overnight urine samples from 60 healthy subjects over three consecutive nights in summer.
    • Repeated urine collections in a subgroup during winter.
    • Analyzed 6-hydroxymelatonin excretion as a marker for melatonin production.
    • Balanced the subject sample for age and sex.

    Main Results:

    • Melatonin production showed a significant decline with increasing age.
    • No significant influence of season (summer vs. winter) on melatonin production was observed.
    • Other demographic variables, including sex, did not significantly affect melatonin levels.

    Conclusions:

    • Age is a significant factor in the reduction of melatonin production in humans.
    • Seasonal variations do not appear to substantially alter melatonin production in this cohort.
    • Further research may explore other physiological or environmental factors affecting melatonin amplitude.

    Related Experiment Videos