Related Experiment Video
Updated: Jul 13, 2025
12:16
A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
Published on: October 16, 2018
14.8K
B Cell Tolerance and Targeted Therapies in SLE
Ioannis Parodis1,2,3, Xuan Long4, Mikael C I Karlsson5
1Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, 17177 Stockholm, Sweden.
Journal of Clinical Medicine
|October 14, 2023
Summary
Systemic Lupus Erythematosus (SLE) is a complex autoimmune disease driven by B cell dysfunction. This review explores B cell biology, immune interactions, and targeted therapies for SLE.
Area of Science:
- Immunology
- Autoimmunity
- Rheumatology
Background:
- Systemic Lupus Erythematosus (SLE) is a heterogeneous autoimmune disease characterized by immune system dysregulation.
- B cell hyperactivity and autoantibody production are central to SLE pathogenesis.
- The intricate interplay between innate and adaptive immunity in SLE remains incompletely understood.
Purpose of the Study:
- To review current knowledge on B cell development, tolerance, and function in SLE.
- To discuss the regulation of B cells by various immune cells.
- To examine B cell-targeted therapies and future research directions.
Main Methods:
- Literature review of recent advancements in B cell biology and SLE.
- Analysis of immune cell interactions in the context of lupus autoimmunity.
- Synthesis of information on current and emerging therapeutic strategies.
Main Results:
- B cell development, maturation, and tolerance mechanisms are critical in SLE.
- Dysregulation of B cells by T cells, granulocytes, and other immune cells contributes to SLE.
- Effector B cells play a significant role in SLE pathophysiology.
Conclusions:
- Understanding B cell biology is key to unraveling SLE pathogenesis.
- Targeting B cells offers promising therapeutic avenues for SLE treatment.
- Further research into immune cell interactions will guide future SLE management strategies.
More Related Videos
Related Concept Videos
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
01:20Special Features of Adaptive Immunity
841
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
841
01:24B Cell Activation and Differentiation
1.8K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.8K
01:27Tumor Immunotherapy
539
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
539
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
150
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
150
01:24T Cell Types and Functions
1.0K
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
1.0K