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Depressed Mood as a Significant Risk Factor for Gynecological Cancer Aggravation.

Seon-Mi Lee1, Jae-Yun Song1, Aeran Seol1

  • 1Department of Obstetrics and Gynecology, Korea University College of Medicine, Korea University Anam Hospital, Seoul 02841, Republic of Korea.

International Journal of Environmental Research and Public Health
|October 14, 2023
PubMed
Summary
This summary is machine-generated.

Depressed mood is linked to poorer disease-free survival in gynecological cancer patients. Addressing depression alongside cancer treatment may reduce cancer aggravation risks.

Keywords:
cancer aggravationdepressed mooddepressiongynecological cancerrisk factors

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Area of Science:

  • Gynecologic Oncology
  • Psychosomatic Medicine
  • Cancer Survivorship

Background:

  • Investigating the impact of mental health on gynecological cancer prognosis.
  • Identifying psychological factors influencing cancer progression and outcomes.

Purpose of the Study:

  • To evaluate the association between depressed mood and gynecological cancer outcomes.
  • To identify risk factors contributing to cancer aggravation in these patients.

Main Methods:

  • Retrospective analysis of 217 gynecological cancer patients (Jan 2020-Aug 2022).
  • Utilized Patient Health Questionnaire-9 (PHQ-9) to assess mood.
  • Employed statistical analyses including Kaplan-Meier and Cox regression.

Main Results:

  • Depressed mood (DM) group (88 patients) showed significantly lower two-year disease-free survival (DFS) (86.4%) compared to non-depressed mood (NDM) group (93.6%) (p=0.006).
  • Overall survival (OS) did not differ significantly between groups (p=0.128).
  • Advanced stage (≥3), multiple chemotherapies (≥5), post-chemotherapy side effects, and depressed mood were associated with increased cancer aggravation risk.

Conclusions:

  • Treating depressed mood in gynecological cancer patients is crucial.
  • Integrated care addressing psychological state, advanced cancer, chemotherapy burden, and side effects may mitigate cancer aggravation.