Related Experiment Video
Updated: Jul 13, 2025
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Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
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Prognostic Role of KRAS G12C Mutation in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
Durgesh Wankhede1, Christophe Bontoux2, Sandeep Grover3
1Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany.
Diagnostics (Basel, Switzerland)
|October 14, 2023
Summary
The KRAS G12C mutation negatively impacts survival in non-small cell lung cancer patients, indicating it
Area of Science:
- Oncology
- Genetics
- Cancer Research
Background:
- KRAS G12C mutation is the most frequent KRAS mutation in non-small cell lung cancer (NSCLC).
- It serves as a predictive biomarker for KRAS G12C inhibitors in advanced solid cancers.
Purpose of the Study:
- To determine the prognostic significance of KRAS G12C mutations in NSCLC patients.
- To compare survival outcomes between KRAS G12C mutated tumors and KRAS-WT or other KRAS mutated tumors.
Main Methods:
- A meta-analytic approach was used, searching PubMed, EMBASE, Cochrane Library, and Clinicaltrials.gov.in.
- Included prospective or retrospective studies reporting survival data.
- Hazard ratios for overall survival (OS) and disease-free survival (DFS) were pooled using fixed or random-effects models.
Main Results:
- KRAS G12C tumors showed poorer OS compared to KRAS-WT tumors (HR, 1.42; 95% CI, 1.10-1.84).
- KRAS G12C tumors had poorer DFS compared to other KRAS mutations (HR, 1.49; 95% CI, 1.07-2.09).
- High PD-L1 expression (>50%) was associated with KRAS G12C tumors compared to other KRAS mutations (OR 1.37; 95% CI 1.11-1.70).
Conclusions:
- KRAS G12C is a significant prognostic factor in NSCLC, negatively impacting survival.
- High PD-L1 expression in KRAS G12C tumors suggests potential therapeutic strategies.
- Heterogeneity and selection bias may affect the findings' validity.
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