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Acoustofluidics-Assisted Coating of Microparticles.

Ming-Lin Yeh1, Geng-Ming Chang1, Yi-Je Juang1,2,3

  • 1Department of Chemical Engineering, National Cheng Kung University, No. 1 University Road, Tainan 70101, Taiwan.

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|October 14, 2023
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Summary

This study demonstrates rapid microparticle coating using acoustofluidics. The microfluidic method offers more uniform zeta potentials compared to traditional batch methods for enhanced particle functionality.

Keywords:
conformal coatingmicrofluidicspolydimethylsiloxanepolyelectrolytetraveling surface acoustic wave

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Area of Science:

  • Materials Science
  • Chemical Engineering
  • Nanotechnology

Background:

  • Microparticles are versatile materials used in diverse applications like drug delivery and diagnostics.
  • Surface coating enhances microparticle functionality, offering benefits such as controlled release and improved stability.

Purpose of the Study:

  • To propose and demonstrate a conformal coating method for microparticles using a positively charged polyelectrolyte (polyallylamine hydrochloride, PAH).
  • To investigate the efficiency and uniformity of microparticle coating via an acoustofluidic microchip compared to batch methods.

Main Methods:

  • Utilized an acoustofluidic microchip to create multiple laminar streams of PAH solution and microparticles.
  • Employed traveling surface acoustic waves to guide microparticles through the streams for rapid, conformal coating.
  • Investigated the effect of microchannel width and PAH concentration on zeta potential.

Main Results:

  • Achieved rapid coating of microparticles using the microfluidic approach, outperforming traditional batch methods.
  • Demonstrated more uniform zeta potentials for microparticles coated via the microfluidic method.
  • Observed charge reversal and increased zeta potential with increasing microchannel width or PAH concentration for unfunctionalized microparticles.

Conclusions:

  • The acoustofluidic microchip provides an efficient and rapid method for conformal microparticle coating.
  • This microfluidic technique yields more uniform surface charge distribution, crucial for controlled applications.
  • The study highlights the potential of acoustofluidics for tailored microparticle surface modification.