Childhood lymphoma in southern Iran

A study of 81 childhood lymphomas diagnosed in the Department of Pathology of Pahlavi University Medical Center, Shiraz, Iran, encompassing all histologically diagnosed childhood lymphomas from the Fars Province, Southern Iran over a 14-year period (1963--1976) revealed a 3:1 male predominance and a 1:4 frequency compared to adult lymphomas. Peripheral lymphadenopathy at the initial physical examination was almost twice as common as deep node involvement. Comparison of cumulative and age-standardized (to world population) incidence rates with those of selected Tumor Registries in various continents revealed a higher rate in our region of both non-Hodgkin's and Hodgkin's lymphoma relative to some of the Western countries. Our incidence rates were in general intermediate between Western populations on one hand and some South America, African and Asian populations on the other. Hodgkin's disease accounted for 64% (males) and 88% (females) of lymphomas and mixed cellularity was the commonest histologic subtype. Histologically almost all non-Hodgkin's lymphomas were diffuse at the time of diagnosis.