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Formation of Complex Ions

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...

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Synthesis of Multi-walled Carbon Nanotubes Modified with Silver Nanoparticles and Evaluation of Their Antibacterial Activities and Cytotoxic Properties

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2-Pyridinecarboxaldehyde-Modified Chitosan-Silver Complexes: Optimized Preparation, Characterization, and

Zhaoyu Zhang¹, Yurong Zhao¹, Zhang Hu¹

¹Faculty of Chemistry and Environmental Science, Guangdong Ocean University, Zhanjiang 524088, China.

Molecules (Basel, Switzerland)

|October 14, 2023

Summary

Antibiotic-free 2-pyridinecarboxaldehyde-grafted chitosan-silver (PCA-CS-Ag) complexes show potent antibacterial activity. Optimized preparation yields high silver content, demonstrating broad-spectrum efficacy against bacteria for various applications.

Keywords:

antibacterial complex modified chitosan response surface methodology silver

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Area of Science:

Materials Science
Biotechnology
Nanotechnology

Background:

Infectious bacteria pose a significant public health threat, necessitating novel antibiotic-free antibacterial materials.
Chitosan (CS) is a biocompatible polymer with potential antibacterial properties, but its efficacy can be enhanced.

Purpose of the Study:

To develop and optimize an efficient, broad-spectrum, antibiotic-free antibacterial material.
To synthesize and characterize 2-pyridinecarboxaldehyde-grafted chitosan-silver (PCA-CS-Ag) complexes.
To evaluate the antibacterial activity and potential applications of the synthesized complexes.

Main Methods:

Grafting 2-pyridinecarboxaldehyde (PCA) onto chitosan (CS) followed by coordination with silver ions (Ag).
Optimization of PCA-CS-Ag complex preparation using single-factor experiments and response surface methodology.
Structural characterization via UV-Vis, FTIR, 1H NMR, and TGA; antibacterial assays in vitro; molecular mechanics calculations.

Main Results:

Optimized conditions yielded PCA-CS-Ag complexes with a high silver content of 13.27 mg/g.
Structural analysis confirmed the formation and composition of the PCA-CS-Ag complex.
In vitro tests demonstrated strong antibacterial activity against both Gram-positive and Gram-negative bacteria.

Conclusions:

The PCA-CS-Ag complex exhibits a synergistic antibacterial effect from modified chitosan and silver ions.
This novel material shows promise as an effective antibacterial agent.
Potential applications include food films, packaging, and medical dressings, offering an alternative to conventional antibiotics.