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Bufotalin Suppresses Proliferation and Metastasis of Triple-Negative Breast Cancer Cells by Promoting Apoptosis and

So Jin Park1, Hye Jin Jung1,2,3

  • 1Department of Life Science and Biochemical Engineering, Graduate School, Sun Moon University, Asan 31460, Republic of Korea.

Molecules (Basel, Switzerland)
|October 14, 2023
PubMed

Insights

Bufotalin, a natural compound, effectively inhibits triple-negative breast cancer (TNBC) growth and metastasis. It works by inducing apoptosis and suppressing key pathways involved in cancer progression.

Area of Science:

  • Pharmacology
  • Oncology
  • Natural Products Chemistry

Background:

  • Triple-negative breast cancer (TNBC) is aggressive with poor prognosis.
  • Existing treatments face challenges with drug resistance and recurrence.
  • Novel therapeutic strategies for TNBC are urgently needed.

Purpose of the Study:

  • To investigate the anticancer effects of bufotalin on TNBC cells.
  • To elucidate the molecular mechanisms underlying bufotalin's action in TNBC.
  • To evaluate bufotalin's potential as a new therapeutic agent for TNBC.

Main Methods:

  • Utilized TNBC cell lines (MDA-MB-231 and HCC1937).
  • Assessed bufotalin's impact on cell proliferation, apoptosis, migration, and invasion.
  • Analyzed key molecular markers including EMT biomarkers, MMPs, integrin α6, and the STAT3 pathway.

Main Results:

  • Bufotalin significantly inhibited TNBC cell proliferation via cell cycle arrest and apoptosis.
  • Bufotalin suppressed TNBC cell migration and invasion.
  • Bufotalin's anticancer activity was linked to STAT3 pathway downregulation and modulation of EMT axis.

Conclusions:

  • Bufotalin demonstrates potent antiproliferative and antimetastatic effects in TNBC.
  • Bufotalin may represent a promising natural compound for TNBC treatment.
  • The STAT3/EMT pathway is a key target for bufotalin's action in TNBC.
Keywords:
apoptosisbufotalinepithelial-mesenchymal transitionsignal transducer and activator of transcription 3triple-negative breast cancer

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