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Annona cherimola Seed Extracts Trigger an Early Apoptosis Response and Selective Anticlonogenic Activity against the

Johan Macuer-Guzmán1,2, Claudia Giovagnoli-Vicuña3, Giuliano Bernal4

  • 1Laboratorio de Silvigenómica y Biotecnología, Departamento de Biología, Facultad de Ciencias, Universidad de La Serena, Avenida Raúl Bitrán 1305, Casilla 599, La Serena 1700000, Chile.

Molecules (Basel, Switzerland)
|October 14, 2023
PubMed

Insights

Annona cherimola seed extract shows potential as a natural therapy for gastric cancer by inhibiting tumor cell growth and inducing apoptosis. Key compounds identified may be responsible for these promising anticancer effects.

Area of Science:

  • Natural Product Chemistry
  • Oncology
  • Cell Biology

Background:

  • Gastric cancer remains a significant global health challenge.
  • Exploring natural compounds for novel therapeutic strategies is crucial.

Purpose of the Study:

  • To evaluate the antiproliferative and apoptotic effects of Annona cherimola seed extract (EMCHS) on human gastric cancer cells (SNU-1).
  • To identify potential active compounds within the extract responsible for anticancer activity.

Main Methods:

  • Ethanol macerate extract from Annona cherimola seeds (EMCHS) was prepared.
  • Human gastric cancer cell line SNU-1 was treated with varying concentrations of EMCHS.
  • Clonogenic assay and Annexin-V assay were performed to assess antiproliferative and apoptotic effects.
  • UHPLC-MS/MS and GC-FID were used for chemical compound identification.

Main Results:

  • EMCHS significantly reduced the clonogenic capacity of SNU-1 cells at 20 μg/mL.
  • EMCHS induced apoptosis in SNU-1 cells at 50 μg/mL, confirmed by Annexin-V assay.
  • Two acetogenins, Annonacinone and Annonacin, were identified and potentially responsible for antiproliferative effects.
  • Oleic acid, an antitumor adjuvant, was among the identified fatty acids.

Conclusions:

  • EMCHS exhibits significant antiproliferative and apoptotic effects against human gastric cancer cells.
  • Identified acetogenins and fatty acids suggest a potential mechanism for the observed anticancer activity.
  • Annona cherimola seed extract shows promise as a natural therapeutic agent for gastric cancer.
Keywords:
bioactivitycancerous cellsethanolic extractfruit waste

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