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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Updated: Jun 27, 2026

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

Utilization of Plasmonic and Photonic Crystal Nanostructures for Enhanced Micro- and Nanoparticle Manipulation

Published on: September 27, 2011

Plasmonic Nanostructure Biosensors: A Review.

Huimin Wang^1,2, Tao Wang^1,2, Xuyang Yuan^1,2

¹Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China.

Sensors (Basel, Switzerland)

|October 14, 2023

Summary

This review explores plasmonic nanostructure biosensors utilizing surface plasmon resonance (SPR). It details localized surface plasmon resonance (LSPR) and propagating surface plasmon polariton (PSPP) principles and applications in biosensing.

Keywords:

plasmon nanoruler plasmonic nanostructure biosensors surface plasmon resonance surface-enhanced Raman scattering

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Area of Science:

Nanotechnology
Biomedical Engineering
Physical Chemistry

Background:

Plasmonic nanostructures offer advanced capabilities in biosensing.
Surface Plasmon Resonance (SPR) is a key optical phenomenon utilized in these sensors.
SPR encompasses localized surface plasmon resonance (LSPR) and propagating surface plasmon polariton (PSPP) modes.

Purpose of the Study:

To elaborate on the physical principles of LSPR and PSPP.
To summarize recent advancements in SPR-based biosensors.
To discuss the future development of plasmonic nanostructure biosensors.

Main Methods:

Review and categorization of SPR biosensors based on sensing principles.
Elaboration of physical principles of LSPR and PSPP.
Discussion of advanced applications like single-molecule detection.

Main Results:

Categorization of biosensors into inherent resonance, plasmon nanoruler, and surface-enhanced Raman scattering types.
Demonstration of plasmonic nanostructures for refractive index sensing, nanoscale distance measurement, and signal amplification.
Exploration of metal nanoparticles and nanopores for single-molecule detection.

Conclusions:

Plasmonic nanostructure biosensors are versatile tools with diverse sensing mechanisms.
Continued development promises enhanced sensitivity and novel applications, including single-molecule detection.
Future research directions focus on optimizing nanostructure design and integration for improved biosensing performance.