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Type 2 diabetes aggravates periodontitis-induced pathological changes in the dental pulp
Tao Yang1, Bowen Zhou1, Zhaochen Shan1
1Outpatient Department of Oral and Maxillofacial Surgery, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing, China.
Oral Diseases
|October 14, 2023
Summary
Diabetes worsens dental pulp damage in periodontitis patients by increasing advanced glycation end products (AGEs) and LOX1, leading to inflammation and cell death. Early oral care is crucial for diabetic periodontitis patients.
Area of Science:
- Oral Biology
- Endodontology
- Diabetology
Background:
- The interplay between diabetes and periodontitis on dental pulp pathology remains under-investigated.
- Understanding these mechanisms is crucial for managing patients with both conditions.
Purpose of the Study:
- To explore the pathological changes in dental pulp influenced by diabetes and periodontitis.
- To elucidate the molecular mechanisms underlying these changes.
Main Methods:
- Collected dental pulp samples from healthy individuals and patients with periodontitis (with or without diabetes).
- Performed morphological analysis, and assessed advanced glycation end products (AGEs), LOX1, oxidative stress (OS), inflammation, and apoptosis.
Main Results:
- Diabetic periodontitis (DP) group showed sparse, disordered pulp structure and thickened blood vessels.
- Upregulation of AGEs and LOX1, decreased superoxide dismutase 2, and increased OS, inflammation, and apoptosis were observed in DP patients.
- Elevated OS and inflammation correlated with increased apoptosis in the DP group.
Conclusions:
- Diabetes exacerbates dental pulp pathology in periodontitis, potentially via AGEs and LOX1 pathways.
- Highlights the significance of early oral interventions for patients with diabetic periodontitis.
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