Phase-separation multiphase flow: preliminary application to analytical chemistry.

Area of Science:

• Analytical Chemistry
• Fluid Dynamics
• Chemical Engineering

Background:

• Two-phase separation solutions exhibit reversible phase transitions triggered by temperature and/or pressure.
• Phase transitions within microspace regions induce dynamic liquid-liquid interfaces, forming multiphase structures known as phase-separation multiphase flows.
• Annular flow in microspaces is a significant type of phase-separation multiphase flow with established applications.

Purpose of the Study:

• To review research on phase-separation multiphase flows from discovery to current technical advancements.
• To explore the fundamental principles and applications of these flows in analytical science.
• To introduce novel separation modes developed using phase-separation multiphase flow in high-performance liquid chromatography (HPLC).

Main Methods:

• Literature review of phase-separation multiphase flow research.
• Analysis of fundamental principles governing phase transitions and interface dynamics.
• Examination of applications in chromatography, extraction, reaction fields, and mixing.
• Introduction of a new separation mode in HPLC systems.

Main Results:

• Phase-separation multiphase flows are characterized by dynamic interfaces and reversible transitions.
• These flows have demonstrated utility in various analytical and chemical processes.
• A novel separation mode leveraging phase-separation multiphase flow in HPLC has been developed.

Conclusions:

• Phase-separation multiphase flow is a critical phenomenon with broad applicability in analytical science.
• Continued research is vital for understanding and optimizing these flows for advanced separation technologies.
• The development of new HPLC separation modes highlights the practical potential of this flow regime.