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Related Experiment Video

Updated: Jul 13, 2025

Author Spotlight: Enhancing Microinjection Needle Quality by Wet Beveling

Author Spotlight: Enhancing Microinjection Needle Quality by Wet Beveling

Published on: September 27, 2024

A new flow-based design for double-lumen needles.

Radu Cimpeanu¹, Alfonso A Castrejón-Pita², Lee Nai Lim³

¹Mathematics Institute, University of Warwick, Coventry, CV4 7AL, United Kingdom; Mathematical Institute, University of Oxford, Oxford, OX2 6GG, United Kingdom.

Journal of Biomechanics

|October 14, 2023

Summary

This summary is machine-generated.

A new OxIVF needle improves oocyte retrieval in in vitro fertilization (IVF) by using hydrodynamics for gentle, effective fluid flow. This novel needle achieves up to 100% success, surpassing traditional methods and maximizing oocyte yield.

Keywords:

Direct numerical simulation In-vitro fertilisation Interfacial flow Needle Vortex dynamics

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Last Updated: Jul 13, 2025

Author Spotlight: Enhancing Microinjection Needle Quality by Wet Beveling

Author Spotlight: Enhancing Microinjection Needle Quality by Wet Beveling

Published on: September 27, 2024

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Construction and Implantation of a Microinfusion System for Sustained Delivery of Neuroactive Agents.

Published on: March 17, 2008

Apparatus for Harvesting Tissue Microcolumns

Apparatus for Harvesting Tissue Microcolumns

Published on: October 25, 2018

Area of Science:

Reproductive Medicine
Biomedical Engineering
Fluid Dynamics

Background:

Oocyte retrieval is critical for in vitro fertilization (IVF) success.
Standard needles have limitations in efficiency and cost-effectiveness.
Novel approaches are needed to enhance oocyte retrieval outcomes.

Purpose of the Study:

To introduce and evaluate a novel hydrodynamics-based needle, the OxIVF needle, for improved oocyte retrieval.
To compare the efficacy of the OxIVF needle against traditional double-lumen needles.
To assess the impact of the OxIVF needle on oocyte stress and trajectory during retrieval.

Main Methods:

Development of a two-dimensional digital twin of the follicular environment.
Utilizing multi-phase flow direct numerical simulation to model fluid dynamics.
Varying oocyte initial locations and measuring key fluid parameters like velocity and vorticity.

Main Results:

The OxIVF needle demonstrated a superior success rate of up to 100%, compared to traditional needles (≤75%).
Oocyte retrieval success with the OxIVF needle was independent of needle tip location.
Simulations showed minimal stress on the oocyte, with a gentle flow guiding it towards extraction.

Conclusions:

The OxIVF needle offers a significant advancement in oocyte retrieval technology.
Its hydrodynamics-based design enhances efficiency and reduces oocyte stress.
This innovation holds potential for improving IVF outcomes in both human and veterinary applications.