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Versatile function of AMPK signaling in osteosarcoma: An old player with new emerging carcinogenic functions

Mehrdad Hashemi1, Mehrnaz Razzazan2, Maryam Bagheri3

  • 1Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Farhikhtegan Medical Convergence Sciences Research Center, Farhikhtegan Hospital Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.

Pathology, Research and Practice
|October 14, 2023
PubMed

Insights

AMP-activated protein kinase (AMPK) signaling plays a complex role in osteosarcoma (OS) progression and treatment. Understanding AMPK

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Osteosarcoma (OS) is an aggressive bone cancer with poor prognosis, especially in metastatic or recurrent cases.
  • AMP-activated protein kinase (AMPK) signaling is implicated in various cellular processes relevant to cancer.
  • The precise role of AMPK in OS remains complex, with potential dual functions as a tumor suppressor or promoter.

Purpose of the Study:

  • To review the regulatory mechanisms and functional roles of AMPK signaling in osteosarcoma.
  • To explore the therapeutic potential of targeting AMPK signaling for OS treatment.
  • To highlight the need for further research into AMPK's mechanisms and therapeutic applications in OS.

Main Methods:

  • Literature review of studies on AMPK signaling in osteosarcoma.
  • Analysis of molecular activation pathways of AMPK.
  • Examination of AMPK's interaction with cellular proliferation, apoptosis, and metabolism in OS.
  • Review of therapeutic agents targeting AMPK signaling.

Main Results:

  • AMPK signaling influences key cellular processes in OS, including proliferation, apoptosis, and metabolism.
  • AMPK can act as both a tumor suppressor and a promoter in cancer, including OS.
  • Several compounds like metformin and resveratrol show potential for targeting AMPK in OS treatment.

Conclusions:

  • AMPK signaling is intricately involved in osteosarcoma, necessitating a comprehensive understanding of its molecular mechanisms.
  • Targeting AMPK signaling presents a promising avenue for novel therapeutic strategies in OS.
  • Further research is crucial to optimize dosing, understand toxicities, and elucidate the precise anti-osteosarcoma effects of AMPK-targeting agents.
Keywords:
AMP-activated protein kinaseCarcinogenicDrug resistanceOsteosarcomaSignaling

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