Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Feedback control systems01:26

Feedback control systems

319
Feedback control systems are categorized in various ways based on their design, analysis, and signal types.
Linear feedback systems are theoretical models that simplify analysis and design. These systems operate under the principle that their output is directly proportional to their input within certain ranges. For instance, an amplifier in a control system behaves linearly as long as the input signal remains within a specific range. However, most physical systems exhibit inherent nonlinearity...
319
Control Systems01:10

Control Systems

1.2K
Control systems are everywhere in contemporary society, influencing diverse applications from aerospace to automated manufacturing. These systems can be found naturally within biological processes, such as blood sugar regulation and heart rate adjustment in response to stress, as well as in man-made systems like elevators and automated vehicles. A control system is essentially a network of subsystems and processes that collaboratively convert specific inputs into desired outputs.
At the heart...
1.2K
Open and closed-loop control systems01:17

Open and closed-loop control systems

769
Control systems are foundational elements in automation and engineering. They are broadly categorized into open-loop and closed-loop systems. These classifications hinge on the presence or absence of feedback mechanisms, significantly influencing the system's performance, complexity, and application.
An open-loop control system operates without feedback from the output. It consists of two primary elements: the controller and the controlled process. The controller receives an input signal...
769
Control System Problem01:21

Control System Problem

121
In an open-loop system, such as a basic thermostat, the poles of the transfer function influence the system's response but do not determine its stability. However, when feedback is introduced to form a closed-loop system, such as an advanced thermostat that adjusts heating based on room temperature, stability is governed by the new poles of the closed-loop transfer function.
When forming a closed-loop system, issues can arise if the poles cross into the unstable region, leading to potential...
121
Classification of Systems-I01:26

Classification of Systems-I

192
Linearity is a system property characterized by a direct input-output relationship, combining homogeneity and additivity.
Homogeneity dictates that if an input x(t) is multiplied by a constant c, the output y(t) is multiplied by the same constant. Mathematically, this is expressed as:
192
Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding01:22

Nonlinear Pharmacokinetics: Bioavailability and Protein-Drug Binding

190
When a drug follows nonlinear pharmacokinetics, its bioavailability, the amount of the drug that reaches the systemic circulation, can change with different doses. This is due to the presence of a saturable pathway. The pathway becomes saturated as the drug concentration increases, decreasing the absorption rate. Consequently, the drug's bioavailability may be lower than expected at higher doses.
To quantify the extent of bioavailability, pharmacologists often use a parameter called .
190

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leveraging mathematical models to predict and control T-cell activation.

PLoS computational biology·2026
Same author

Analysing the Structural Identifiability and Observability of Mechanistic Models of Tumour Growth.

Bioengineering (Basel, Switzerland)·2025
Same author

Employing Observability Rank Conditions for Taking into Account Experimental Information a priori.

Bulletin of mathematical biology·2025
Same author

Corrigendum to "Controllability and accessibility analysis of nonlinear biosystems" [Computer Methods and Programs in Biomedicine 242 (2023) 107837].

Computer methods and programs in biomedicine·2024
Same author

Distilling identifiable and interpretable dynamic models from biological data.

PLoS computational biology·2023
Same author

Structural Identifiability and Observability of Microbial Community Models.

Bioengineering (Basel, Switzerland)·2023

Related Experiment Video

Updated: Jul 13, 2025

An Experimental Platform to Study the Closed-loop Performance of Brain-machine Interfaces
10:51

An Experimental Platform to Study the Closed-loop Performance of Brain-machine Interfaces

Published on: March 10, 2011

13.8K

Controllability and accessibility analysis of nonlinear biosystems.

Sandra Díaz-Seoane1, Antonio Barreiro Blas1, Alejandro F Villaverde2

  • 1Universidade de Vigo, Department of Systems Engineering & Control, 36310 Vigo, Galicia, Spain.

Computer Methods and Programs in Biomedicine
|October 14, 2023
PubMed
Summary

This study introduces a novel method for assessing the controllability and accessibility of nonlinear biosystems. The developed algorithm and open-source tool efficiently analyze complex biological models, revealing limitations in some signaling networks.

Keywords:
AccessibilityComputational methodsControllabilityModelingSignalling pathways

More Related Videos

WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control
08:18

WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control

Published on: August 15, 2020

5.0K
Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
11:54

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface

Published on: May 8, 2021

4.4K

Related Experiment Videos

Last Updated: Jul 13, 2025

An Experimental Platform to Study the Closed-loop Performance of Brain-machine Interfaces
10:51

An Experimental Platform to Study the Closed-loop Performance of Brain-machine Interfaces

Published on: March 10, 2011

13.8K
WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control
08:18

WheelCon: A Wheel Control-Based Gaming Platform for Studying Human Sensorimotor Control

Published on: August 15, 2020

5.0K
Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface
11:54

Real-Time Proxy-Control of Re-Parameterized Peripheral Signals using a Close-Loop Interface

Published on: May 8, 2021

4.4K

Area of Science:

  • Systems Biology
  • Control Theory
  • Biomedical Engineering

Background:

  • Nonlinear biosystems are crucial for understanding biological processes.
  • Controllability and accessibility analysis is challenging for nonlinear systems.

Purpose of the Study:

  • To develop methods for determining controllability and accessibility in nonlinear biosystems.
  • To provide a general test for nonlinear system analysis.

Main Methods:

  • Utilized differential geometric control theory.
  • Derived sufficient conditions for controllability and necessary/sufficient conditions for accessibility.
  • Developed an efficient algorithmic procedure and open-source implementation.

Main Results:

  • Successfully analyzed accessibility and controllability of various biomedical models.
  • Identified specific models, like EGF and NFκB signaling networks, as not fully controllable.
  • Provided an efficient computational tool for these analyses.

Conclusions:

  • The developed methods enhance the analysis of nonlinear models in biomedicine.
  • This work facilitates broader application of controllability and accessibility analysis in diverse scientific fields.