Comparison of IPSS score and voiding parameters in men presenting with LUTS

Area of Science:

• Urology
• Andrology
• Medical Diagnostics

Background:

• Lower urinary tract symptoms (LUTS) are common in men with benign prostatic hyperplasia (BPH).
• Subjective symptom scores, like the International Prostate Symptom Score (IPSS), are frequently used for LUTS assessment.
• Objective voiding parameters provide quantitative measures of bladder outlet obstruction.

Purpose of the Study:

• To compare subjective LUTS (IPSS) with objective voiding parameters obtained via the UroCuff Test.
• To evaluate the correlation between self-reported symptoms and urodynamic measurements in men with BPH-related LUTS.

Main Methods:

• Analysis of an expanded subpopulation (1077 men) from a larger LUTS cohort.
• Optional collection of International Prostate Symptom Score (IPSS) during the non-invasive UroCuff Test (a pressure flow study).
• Statistical analysis included descriptive statistics, correlation coefficients, and multivariable linear regression.

Main Results:

• Weak, yet statistically significant, correlations were found between IPSS and objective parameters: maximum flow rate (Qmax), voided volume (VV), post-void residual volume (PVR), and UroCuff quadrant.
• Increased age and high VV were associated with decreased IPSS, while high PVR correlated with increased IPSS.
• These associations weakened with increasing disease progression.

Conclusions:

• Self-reported LUTS (IPSS) alone are insufficient for definitive diagnosis due to weak correlation with objective voiding parameters.
• Optimal management of male LUTS requires integrating both subjective symptom assessment and objective voiding parameter evaluation.
• The UroCuff Test offers a non-invasive method for obtaining objective voiding parameters.